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Having defeated the rival gangs of Stilwater at the end of Saints Row 2 and overthrown the influence of the Ultor Corporation, the Saints have turned into national superstars, and they have their own energy drink, clothing line, and fanbase. They target a bank, attempting to airlift the vault out of it, but the alarm alerts the Stilwater PD and the Saints are incarcerated. In prison, they learn that the bank they tried to rob was owned by a huge international crime organization called The Syndicate, led by Phillipe Loren. After bribing the police, the Syndicate capture the Saints' leader, Johnny Gat, and Shaundi to try and negotiate a business plan with them, aboard Loren's private jet. While in-flight, Loren tells them they will be allowed to live if they turn over two-thirds of their territory in Stilwater. The leader of the Saints rejects this offer, and a gunfight breaks out, with the Saint's leader and Shaundi escaping from the jet while Johnny Gat holds back their enemies to buy them time. It is unknown if Johnny Gat survives or not.
With the Syndicate in full control of Stilwater, the Saints relocate themselves to the city of Steelport. Pierce is instructed to remain in Stilwater to make sure everything runs smoothly. Steelport is a city that was created as factories flourished with little city planning, and since has suffered from economic failure, contrasting the glamour of Stilwater. The Syndicate has already begun to take control of some parts of Steelport, focusing on vices like merchandise and gambling. To extend their reach, the Syndicate had divided their control of the city through three gangs. The Morning Star, lead by Loren directly, are typically European men with impeccable taste who sell guns. The Mexican wrestler Killbane controls the Luchadores, who deal with gambling and drug smuggling. The Deckers, led by hacktivist Matt Miller, are computer geniuses, and handle money laundering. The Saints see the opportunity to take control of Steelport from these groups. As the war between the gangs intensifies, government trained Special Tactical Anti-Gang (STAG) units will attempt to halt any violent activity whether it be perpetrated by the Saints or the Syndicate.
Much like previous Saints Row games, several celebrities voice characters in the game. Daniel Dae Kim reprises his role as Johnny Gat, Sasha Grey voices Viola DeWynter, Hulk Hogan voices professional wrestler and Saints ally Angel De LaMuerte , and Natalie Lander voices ex-FBI agent and Saints ally Kinzie Kensington. Game designer Tomonobu Itagaki also stars in the game as a playable character.
With the Syndicate in full control of Stilwater, the Saints relocate themselves to the city of Steelport. Pierce is instructed to remain in Stilwater to make sure everything runs smoothly. Steelport is a city that was created as factories flourished with little city planning, and since has suffered from economic failure, contrasting the glamour of Stilwater. The Syndicate has already begun to take control of some parts of Steelport, focusing on vices like merchandise and gambling. To extend their reach, the Syndicate had divided their control of the city through three gangs. The Morning Star, lead by Loren directly, are typically European men with impeccable taste who sell guns. The Mexican wrestler Killbane controls the Luchadores, who deal with gambling and drug smuggling. The Deckers, led by hacktivist Matt Miller, are computer geniuses, and handle money laundering. The Saints see the opportunity to take control of Steelport from these groups. As the war between the gangs intensifies, government trained Special Tactical Anti-Gang (STAG) units will attempt to halt any violent activity whether it be perpetrated by the Saints or the Syndicate.
Much like previous Saints Row games, several celebrities voice characters in the game. Daniel Dae Kim reprises his role as Johnny Gat, Sasha Grey voices Viola DeWynter, Hulk Hogan voices professional wrestler and Saints ally Angel De LaMuerte , and Natalie Lander voices ex-FBI agent and Saints ally Kinzie Kensington. Game designer Tomonobu Itagaki also stars in the game as a playable character.